What is PDRN&PN ?
PDRN consists of DNA fragments with a molecular weight range of approximately 50–1,500 kDa, typically extracted from salmon milt, and features a characteristic double-helix structure.
PN stands for Polynucleotide, a high-molecular-weight nucleic acid, usually higher than 1,500 kDa, active material mostly extracted from salmon milts. With a 3D scaffold structure and excellent biocompatibility, it stimulates fibroblasts to boost collagen regeneration and delivers long-term dermal repair. It is widely applied in regenerative aesthetic medicine and premium skincare.
Mechanism of Action
From DNA fragments to cellular repair signals
DNase Degradation
PDRN is degraded by DNases into oligonucleotides and nucleotides.
A2A Receptor Signaling
Nucleotides participate in cellular endocytic pathways via A2A receptor agonism.
Salvage Pathway
Nucleotides are reused through salvage pathways to support cellular repair and regeneration.
Multi-Effect Benefits
Anti-inflammatory · Repair · Regeneration · Anti-aging · Brightening
Anti-Inflammatory
Helps reduce irritation and supports skin comfort.
Repair
Supports skin barrier function and repair-related cellular processes.
Regeneration
Promotes tissue repair and cellular renewal.
Anti-Aging
Helps improve texture, elasticity, and skin quality.
Skin Brightening
Contributes to a more even and radiant complexion.
History & Applications
PDRN&PN has been researched since the 1950s in Italy, initially for the management of chronic wounds and burns. Over decades, it has evolved into a widely studied bioactive material.
Today, PDRN&PN is widely used in aesthetic injections, advanced skincare formulations, and biotherapeutic fields, making it one of the most promising raw materials in regenerative dermatology and medical aesthetics.
Mincoo PDRN&PN Advantages
With PDRN&PN as our key production technology, Mincoo has built an integrated “Raw materials–Products–Solutions” platform that serves medical aesthetics, skincare, and medical applications globally, aspiring to become China’s leading innovator in advanced PDRN technology.
High Purity
Exclusive separation and extraction technology ensures a purity of over 95%, helping to preserve biological activity and reduce impurity-related risks.
High Safety
Raw materials are traceable and sustainably sourced from the certified FAO61 fishing zone, with low allergenicity and low immunogenicity.
Precise Molecular Weight Control
The average molecular weight range is 100~3,500 kDa, and can be customized according to product positioning and formulation requirements.
Wide Application
Compatible with various dosage forms, including liquid, freeze-dried powder, gel, and other cosmetic or medical-grade formulations.
Supporting Materials
Possessing a complete set of biosafety and efficacy evaluation materials to support product registration and market filing.
Quality System
The production process complies with GMP standards, and key quality parameters are controllable throughout the production life cycle.
Application Fields
Medical/Pharmaceutical · Medical Aesthetics · Personal Care
Medical/Pharmaceutical Field
● Wound healing and tissue repair.
● Diabetic foot and burns.
● Potential use in orthopedics, ophthalmology, and gynecology.
● Broad prospects in regenerative medicine.
Medical Aesthetics
● Skin repair and skin quality improvement.
● Anti-aging and scar fading.
● Application in hydro-injection and microneedle projects.
● Support for post-procedure skin recovery.
Personal Care
● High-end skincare raw materials.● Enhancing product efficacy.
● Development of repair-focused cosmetics.
● Stable maintenance and anti-aging formulation.
